Determinants of eosinophil cationic protein in nasal lavages in children.
Background Nasal lavages are increasingly used to assess airways inflammation in children.
However, there are no studies assessing how measurement error as well as biological influences contribute to the concentration of nasal inflammatory parameters in a population based survey.
Objective To investigate determinants of concentration of eosinophil cationic protein (ECP) in nasal lavages we studied 147 schoolchildren (mean age 8.1 years, so 0.6 years) by repeated nasal lavages/year over a 2 year period.
Methods Standardized questionnaires were completed by the parents each year.
A skin-prick test with seven aeroallergens (birch, cat, dog, hazel, weeds, Dermatophagoides pteronyssinus and D. farinae) was performed.
One hundred and one children could perform valid lavages at least five times a year.
As a measure of reproducibility the intraclass coefficient of reliability was calculated.
Results The intraclass coefficient of reliability was 0.27 over all observations suggesting that about a quarter of total variance is due to between-subject variance.
Taking means over each year increased reliability to 0.60.
Linear regression analyses with ECP being the dependent variable demonstrated significant higher values for boys (bêta=12.26 ; P<0.01), children sensitized to seasonal (bêta=34.27 ; P=0.02) but not to perennial allergens (bêta=-4.44 ; P=0.57), and for children with a serous (bêta=10.01 ; P=0.01) or purulent rhinitis (bêta=22.45 ; P<0.001). (...)
Mots-clés Pascal : Rhinite, Allergie, Lavage, Nez, Enfant, Homme, Autriche, Europe, Allergène, Epidémiologie, ORL pathologie, Nez pathologie, Immunopathologie, Protéine cationique éosinophile, Pneumallergène
Mots-clés Pascal anglais : Rhinitis, Allergy, Washing, Nose, Child, Human, Austria, Europe, Allergen, Epidemiology, ENT disease, Nose disease, Immunopathology, Eosinophil cationic protein, Aeroallergen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0190334
Code Inist : 002B06C02. Création : 11/09/1998.