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  1. Evaluation of a new Near Patient Test for the detection of Helicobacter pylori.

    Article - En anglais

    Objective Peptic ulcer disease is rare in the absence of Helicobacter pylori.

    Testing for H. pylori has recently become easier with the development of Near Patient Tests.

    However, the validity of many of these tests is unknown.

    The aim of this study was to assess the validity of the QuickVue one-step Near Patient Test for H. pylori in a group of patients attending for endoscopy at a tertiary referral hospital.

    Methods In a retrospective study the QuickVue one-step serum test (Quidel) was performed on the stored serum from 193 patients whose H. pylori status had been determined by a'gold standard'using urease testing, histology, culture and 14C-urea breath testing.

    Twenty four other patients presenting to endoscopy were studied prospectively.

    For these patients QuickVue was performed on capillary and venous samples and the results were compared to a similar'gold standard'Enzyme immunoassay (Premier, H. pylori, Meridian Diagnostics, OH, USA) was used to define H. pylori status of patients with indeterminate H. pylori status by the above criteria.

    Results In the retrospective study the QuickVue one-step H. pylori test had a sensitivity (Cl) of 82% (75-89) and specificity of 83% (74-92).

    In the prospective study on capillary blood its sensitivity (Cl) was 89% (52-100) and its specificity 93% (68-100) ; and on venous blood, 78% (40-97) and 93% (68-100).

    Premier has previously been shown to have a sensitivity and specificity of 100%. (...)

    Mots-clés Pascal : Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Diagnostic, Dépistage, Examen laboratoire, Ambulatoire, Evaluation performance, Etude comparative, Homme, Appareil digestif pathologie, Estomac pathologie, Equipement biomédical

    Mots-clés Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Diagnosis, Medical screening, Laboratory investigations, Ambulatory, Performance evaluation, Comparative study, Human, Digestive diseases, Gastric disease, Biomedical equipment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0176507

    Code Inist : 002B24O14. Création : 11/09/1998.