Using birth addresses, we examined the geographical variation in risk for all types of childhood cancers in the UK, on a scale corresponding to the to-km squares of the National Grid.
The effects of socioeconomic and environmental factors, including natural background radiation, were investigated and their relative importance assessed using Poisson regression.
Data came from a national collection of all fatal cancers between 1953 and 1980 in children aged 0-15 years and consisted of 9363 children of known place of birth from 12 complete annual cohorts born in the period 1953-64.
For solid cancers, as well as for leukaemias and lymphomas, there was marked variation of cumulative mortality according to place of birth.
High mortalities were associated with areas characterized as having high social class, higher incomes and good housing conditions, but also with high population densities (births per hectare).
Each of these contrasting social indicators operated independently of the other, indicating complex determining mechanisms.
Mortalities increased with increased radon exposure, and the relationship operated independently of the socioeconomic factors.
At this scale of analysis, we found no increased mortality in industrialized areas. (...)
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Répartition géographique, Loi Poisson, Analyse régression, Mortalité, Epidémiologie, Royaume Uni, Europe, Analyse statistique, Enfant, Homme
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Geographic distribution, Poisson distribution, Regression analysis, Mortality, Epidemiology, United Kingdom, Europe, Statistical analysis, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0175298
Code Inist : 002B04C. Création : 11/09/1998.