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  1. Childhood cancer and paternal employment in agriculture : the role of pesticides.

    Article - En anglais

    Previous studies have suggested that the offspring of men potentially exposed to pesticides at work may be at increased risk of kidney cancer (Wilms'tumour), brain tumours, Ewing's bone sarcoma and acute leukaemia.

    This paper examines the association between potential occupational exposure of fathers to pesticides and offspring's death from cancer in a large national database.

    Records for 167 703 childhood deaths occurring during 1959-63,1970-78 and 1979-90 in England and Wales have been analysed.

    Among the offspring of men with potential occupational exposure to pesticides there were 5270 deaths, of which 449 were due to cancer.

    Associations were assessed using proportional mortality ratios (PMRs), with adjustment for age, year of death and paternal social class.

    Of the childhood cancers previously linked with potential paternal occupational exposure to pesticides, the only statistically significant excess was for kidney cancer (PMR=1.59,95% Cl=1.18-2.15, based on 42 deaths).

    Although these results offer some support for the suggestion that paternal occupational exposure to pesticides may be related to the subsequent development of kidney cancer in offspring, other explanations cannot be excluded.

    In the light of the findings presented here and elsewhere, further, more detailed, research into the nature of this relationship is warranted.

    Mots-clés Pascal : Tumeur maligne, Rein, Exposition professionnelle, Père, Pesticide, Mortalité, Epidémiologie, Royaume Uni, Europe, Agriculture, Enfant, Homme, Appareil urinaire pathologie, Rein pathologie

    Mots-clés Pascal anglais : Malignant tumor, Kidney, Occupational exposure, Father, Pesticides, Mortality, Epidemiology, United Kingdom, Europe, Agriculture, Child, Human, Urinary system disease, Kidney disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0175295

    Code Inist : 002B14D01. Création : 11/09/1998.