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  1. Spatial temporal patterns in childhood leukaemia : further evidence for an infectious origin.

    Article - En anglais

    The EUROCLUS project included information on residence at diagnosis for 13 351 cases of childhood leukaemia diagnosed in the period 1980-89 in defined geographical regions in 17 countries.

    A formal algorithm permits identification of small census areas as containing case excesses.

    The present analysis examines spatial-temporal patterns of the cases (n=970) within these clustered areas.

    The objectives were, first, to compare these results with those from an analysis conducted for UK data for the period 1966-83, and, second, to extend them to consider infant leukaemias.

    A modification of the Knox test investigates, within the small areas, temporal overlap between cases in a subgroup of interest at a putative critical time and all other cases at any time between birth and diagnosis.

    Critical times were specified in advance as follows :

    • for cases of acute lymphoblastic leukaemia aged 2-4 years, the 18-month period preceding diagnosis ;

    • for cases of total leukaemia aged 5-14 years, 1 year before to 1 year after birth ;

    • and for infant cases (diagnosed<1 year), 1 year before to 6 months after birth.

    Each of the analyses found evidence of excess space-time overlap compared with that expected ; these were 10% (P=0.005), 15% (P=0.0002) and 26% (P=0.03) respectively.

    The results are interpreted in terms of an infectious origin of childhood leukaemia.

    Mots-clés Pascal : Leucémie, Répartition spatiale, Distribution temporelle, Etiologie, Infection, In utero, Epidémiologie, Répartition géographique, Enfant, Homme, Hémopathie maligne

    Mots-clés Pascal anglais : Leukemia, Spatial distribution, Time distribution, Etiology, Infection, In utero, Epidemiology, Geographic distribution, Child, Human, Malignant hemopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0175293

    Code Inist : 002B19B. Création : 11/09/1998.