Spatial temporal patterns in childhood leukaemia : further evidence for an infectious origin.
The EUROCLUS project included information on residence at diagnosis for 13 351 cases of childhood leukaemia diagnosed in the period 1980-89 in defined geographical regions in 17 countries.
A formal algorithm permits identification of small census areas as containing case excesses.
The present analysis examines spatial-temporal patterns of the cases (n=970) within these clustered areas.
The objectives were, first, to compare these results with those from an analysis conducted for UK data for the period 1966-83, and, second, to extend them to consider infant leukaemias.
A modification of the Knox test investigates, within the small areas, temporal overlap between cases in a subgroup of interest at a putative critical time and all other cases at any time between birth and diagnosis.
Critical times were specified in advance as follows :
for cases of acute lymphoblastic leukaemia aged 2-4 years, the 18-month period preceding diagnosis ;
for cases of total leukaemia aged 5-14 years, 1 year before to 1 year after birth ;
and for infant cases (diagnosed<1 year), 1 year before to 6 months after birth.
Each of the analyses found evidence of excess space-time overlap compared with that expected ; these were 10% (P=0.005), 15% (P=0.0002) and 26% (P=0.03) respectively.
The results are interpreted in terms of an infectious origin of childhood leukaemia.
Mots-clés Pascal : Leucémie, Répartition spatiale, Distribution temporelle, Etiologie, Infection, In utero, Epidémiologie, Répartition géographique, Enfant, Homme, Hémopathie maligne
Mots-clés Pascal anglais : Leukemia, Spatial distribution, Time distribution, Etiology, Infection, In utero, Epidemiology, Geographic distribution, Child, Human, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0175293
Code Inist : 002B19B. Création : 11/09/1998.