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  1. Occupational lead exposure and screening of glucose-6-phosphate dehydrogenase polymorphism : useful prevention or nonvoluntary discrimination ?

    Article - En anglais

    Objective 

    To discuss regulatory guidelines excluding subjects with erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency from lead-exposed jobs in the light of epidemiology findings on the mortality of these subjects.

    Methods 

    Two mortality follow-up studies were conducted.

    The first comprised 1979 male subjects newly identified as G6PD-deficient during a 1981 screening of the G6PD polymorphism among the general population in Sardinia, Italy.

    The second comprised 1080 male workers employed in maintenance and production departments of a lead smelting plant, who were divided into two subcohorts by erythrocyte G6PD phenotype.

    Results 

    As compared with the general male population, G6PD-deficient subjects had significantly fewer deaths than expected from ischemic heart disease (standardized mortality ratio (SMR)=28 ; 95% CI 10-62), cerebrovascular diseases (SMR=22 ; 95% Cl 6 55), and liver cirrhosis (SMR=12 ; 95% Cl 0-66).

    Among lead smelters the standardized mortality rates from cardiovascular diseases and all cancers observed among the G6PD-deficient subcohort were lower than those seen among subjects with the wild-type G6PD.

    No death from disease of the blood and hematopoietic system was observed among G6PD-deficient subjects in these two follow-up studies.

    Conclusions 

    These studies did not provide evidence of hypersensitivity to lead hematotoxicity among G6PD-deficient individuals at exposure levels within the current standards. (...)

    Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Médecine travail, Détection, Dépistage, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Polymorphisme, Génétique, Recommandation, Législation, Ethique, Déficit, Embauche, Italie, Europe, Recrutement, Bilan santé, Homme

    Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Occupational medicine, Detection, Medical screening, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Polymorphism, Genetics, Recommendation, Legislation, Ethics, Deficiency, Hiring, Italy, Europe, Recruitment, Medical check up, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0172891

    Code Inist : 002B03L05. Création : 11/09/1998.