To discuss regulatory guidelines excluding subjects with erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency from lead-exposed jobs in the light of epidemiology findings on the mortality of these subjects.
Two mortality follow-up studies were conducted.
The first comprised 1979 male subjects newly identified as G6PD-deficient during a 1981 screening of the G6PD polymorphism among the general population in Sardinia, Italy.
The second comprised 1080 male workers employed in maintenance and production departments of a lead smelting plant, who were divided into two subcohorts by erythrocyte G6PD phenotype.
As compared with the general male population, G6PD-deficient subjects had significantly fewer deaths than expected from ischemic heart disease (standardized mortality ratio (SMR)=28 ; 95% CI 10-62), cerebrovascular diseases (SMR=22 ; 95% Cl 6 55), and liver cirrhosis (SMR=12 ; 95% Cl 0-66).
Among lead smelters the standardized mortality rates from cardiovascular diseases and all cancers observed among the G6PD-deficient subcohort were lower than those seen among subjects with the wild-type G6PD.
No death from disease of the blood and hematopoietic system was observed among G6PD-deficient subjects in these two follow-up studies.
These studies did not provide evidence of hypersensitivity to lead hematotoxicity among G6PD-deficient individuals at exposure levels within the current standards. (...)
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Médecine travail, Détection, Dépistage, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Polymorphisme, Génétique, Recommandation, Législation, Ethique, Déficit, Embauche, Italie, Europe, Recrutement, Bilan santé, Homme
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Occupational medicine, Detection, Medical screening, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Polymorphism, Genetics, Recommendation, Legislation, Ethics, Deficiency, Hiring, Italy, Europe, Recruitment, Medical check up, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0172891
Code Inist : 002B03L05. Création : 11/09/1998.