The Finnish occupational exposure limit (OEL) values for alkoxyethanols and their acetates were lowered in 1996.
A reevaluation of the correspondence between the new OEL value and the biological action level (BAL) was thus needed.
This study was conducted in silkscreen printing enterprises, where 2-alkoxyethanols and their acetates are mainly used as solvents.
The air/urine correlations between 2-methoxyethylacetate, 2-ethoxyethylacetate, 2-butoxyethanol, 2-butoxyethylacetate, and 2-methoxyacetic (MAA), 2-ethoxyacetic (EAA), and 2-butoxyacetic acid (BAA) were evaluated on an individual and time-related basis at four different enterprises.
Inhalation exposure to alkoxyalcohols and their acetates was monitored with diffusion badges (n=38) for an entire work week.
Urinary excretion of alkoxyacetic acids immediately after the shift and at 14-16 h after exposure (n=112) was analyzed by a gas chromatograph equipped with a flame-ionization detector.
Inhalation exposure to 2-methoxyethylacetate at 0.5 cm3/m3 corresponded to MAA excretion of 3 mmol/mol creatinine in urine at 14 to 16 hours after exposure.
The next-morning urinary EAA excretion of 37 mmol/mol creatinine corresponded to an 8-h 2-ethoxyethylacetate exposure of 2 cm3/m3 when all collected data were included.
This average EAA excretion was 69% of the German BAT value and only 34% of the American biological exposure index (BEI) value. (...)
Mots-clés Pascal : Concentration maximale admissible, Finlande, Europe, Solvant organique, Lieu travail, Teneur air ambiant, Analyse quantitative, Analyse chimique, Corrélation, Exposition professionnelle, Médecine travail, Inhalation, Urine, Liquide biologique, Surveillance biologique, Ethanol(alcoxy), Acétique acide(acétoxy)
Mots-clés Pascal anglais : Maximum permissible concentration, Finland, Europe, Organic solvent, Work place, Ambient air concentration, Quantitative analysis, Chemical analysis, Correlation, Occupational exposure, Occupational medicine, Inhalation, Urine, Biological fluid, Biological monitoring
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0172886
Code Inist : 002B03L04. Création : 11/09/1998.