logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n-hexane and methyl ethyl ketone.

    Article - En anglais

    Objective 

    MEK (methyl ethyl ketone) is widely and frequently used as an ingredient of mixed solvents together with n-hexane.

    MEK is known to decrease urinary levels of 2,5-hexanedione dose-dependently in an acute or chronic coexposure with a constant level of n-hexane.

    This change in urinary 2,5-hexanedione appears to contradict the potentiation effect of MEK on n-hexane-induced neurotoxicity because it is believed that the toxicity of n-hexane is activated through n-hexane metabolism.

    We aimed to clarify how the urinary level of 2,5-hexanedione changes when MEK modifies the degree of n-hexane-induced neurotoxicity.

    Method 

    A total of 32 male Wistar rats were divided into 4 groups of 8 each and were then exposed to fresh air only, 2000 ppm n-hexane only, 2000 ppm n-hexane plus 200 ppm MEK, and 2000 ppm n-hexane plus 2000 ppm MEK, respectively.

    Inhalation exposures were performed 12 h/day, 6 days/week, for 20 weeks.

    Motor-nerve conduction velocity (MCV), distal latency (DL), and urinary 2,5-hexanedione were measured every 4 weeks.

    Results 

    The MCV decreased, the DL increased, and urinary levels of 2,5-hexanedione increased in the 2000-ppm n-hexane plus 2000 ppm MEK group in comparison with the 2000-ppm n-hexane only group following 4 weeks'exposure.

    On the 1st day of exposure, however, coexposure to MEK decreased urinary levels of 2,5-hexanedione dose-dependently. (...)

    Mots-clés Pascal : Solvant organique, Hexane, Association toxique, Cétone, Butan-2-one, Exposition professionnelle, Médecine travail, Rat, Rodentia, Mammalia, Vertebrata, Toxicité, Potentialisation, Animal, Inhalation, Urine, Liquide biologique, Système nerveux pathologie, Hexane-2,5-dione

    Mots-clés Pascal anglais : Organic solvent, Hexane, Toxic association, Ketone, 2-Butanone, Occupational exposure, Occupational medicine, Rat, Rodentia, Mammalia, Vertebrata, Toxicity, Potentiation, Animal, Inhalation, Urine, Biological fluid, Nervous system diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0172883

    Code Inist : 002B03L04. Création : 11/09/1998.