We evaluated the frequency of congenital chromosomal aberrations in a sample of 305 couples included in an intracytoplasmic sperm injection (ICSI) programme.
Twenty individuals (3.3%) with congenital chromosomal abnormalities could be identified.
The following types of abnormalities were observed : reciprocal translocations (n=7), Robertsonian translocations (n=3), inversions (n=3), other structural aberrations (n=4) and sex chromosome aberrations (n=3).
The rate of chromosomally abnormal males (10/305,3.3%) lay within the expected range for patients with reduced semen quality.
Surprisingly, 50% (10/20) of all abnormal karyotypes were contributed by the female partner of ICSI patients.
These data confirm the higher incidence of chromosomal aberrations in infertile populations as compared with the baseline population risk.
Additionally, the data imply that in some cases of male factor infertility a hidden female chromosomal factor may be present, which cannot be identified by standard clinical evaluation.
In conclusion, we recommend chromosomal analysis in both partners of couples undergoing ICSI treatment.
Mots-clés Pascal : Injection spermatozoïde intracytoplasmique, Fréquence, Aberration chromosomique, Congénital, Cytogénétique, Stérilité mâle, Stérilité femelle, Procréation assistée, Génétique, Epidémiologie, Appareil génital mâle pathologie, Homme, Femelle
Mots-clés Pascal anglais : Intracytoplasmic sperm injection, Frequency, Chromosomal aberration, Congenital, Cytogenetics, Male sterility, Female sterility, Assisted procreation, Genetics, Epidemiology, Male genital diseases, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0172585
Code Inist : 002B20A04. Création : 11/09/1998.