Between 1990 and 1995 39 patients were lung transplanted at the University Hospital in Lund.
This is a retrospective review of survival and lung function in these patients.
There were 17 single-lung transplants (SLT), 21 double-lung transplants (DLT) and 1 heart-lung transplant (HLT).
Seven patients died during the period, giving an overall survival of 82%. One-year survival according to Kaplan-Meier survival analysis was 87%, and 2-year survival was 83%. Vital capacity and forced expiratory volume in 1 s (FEV1) 1 year after transplantation were 91% and 100% of predicted, respectively, in the DLT group and 60% and 50% in the SLT group.
Bronchiolitis obliterans syndrome (BOS) developed in 11 of the 35 patients (31%) surviving more than 6 months, 2/21 in the DLT group and 8/13 in the SLT group and in the patient with HLT.
The median time until detection of BOS was 11 months after the operation (range 6-18 months).
Working capacity 1 year after transplantation was 60% of predicted in the DLT group and 47% of predicted in the SLT group.
Ventilatory capacity was no longer function limiting.
Lung transplantation today is a therapeutic option with a good medium-term survival and good functional results in selected patients with severe lung disease.
Mots-clés Pascal : Homotransplantation, Poumon, Homme, Pronostic, Complication, Survie, Suède, Europe, Epidémiologie, Transplantation, Chirurgie
Mots-clés Pascal anglais : Homotransplantation, Lung, Human, Prognosis, Complication, Survival, Sweden, Europe, Epidemiology, Transplantation, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0171601
Code Inist : 002B25D. Création : 21/07/1998.