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  1. Changes in T cell subpopulations in lead workers.

    Article - En anglais

    To investigate the effects of lead on the human immune system, we analyzed T cell subpopulations and B (CD19+) cells in peripheral blood in 71 male lead workers.

    They were engaged in manufacturing lead stearate in a chemical factory, aged 20 to 74 (mean 48) years.

    Their blood lead concentrations (PbB) were between 7 and 50 (mean 19) mug/dl.

    The control group consisted of 28 « healthy » male volunteers without a history of occupational exposure to lead or other hazardous substances, aged 33 to 67 (mean 55) years.

    In comparison with the controls, a significant reduction in the number of CD3+CD45RO+ (memory T) cells and a significant expansion in the percentage of CD8+cells in the lead workers were found.

    There was a significant positive correlation between the percentage of CD3+CD45RA+ (naive T) cells and PbB in the lead workers.

    It is suggested that CD45RO+memory T cells may be most susceptible to the effects of lead on T cell subpopulations.

    Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Immunopathologie, Lymphocyte T, Lymphocyte B, Sous population cellulaire, Antigène CD45RO

    Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Immunopathology, T-Lymphocyte, B-Lymphocyte, Cell subpopulation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0166971

    Code Inist : 002B03L05. Création : 21/07/1998.