Changes in T cell subpopulations in lead workers.
To investigate the effects of lead on the human immune system, we analyzed T cell subpopulations and B (CD19+) cells in peripheral blood in 71 male lead workers.
They were engaged in manufacturing lead stearate in a chemical factory, aged 20 to 74 (mean 48) years.
Their blood lead concentrations (PbB) were between 7 and 50 (mean 19) mug/dl.
The control group consisted of 28 « healthy » male volunteers without a history of occupational exposure to lead or other hazardous substances, aged 33 to 67 (mean 55) years.
In comparison with the controls, a significant reduction in the number of CD3+CD45RO+ (memory T) cells and a significant expansion in the percentage of CD8+cells in the lead workers were found.
There was a significant positive correlation between the percentage of CD3+CD45RA+ (naive T) cells and PbB in the lead workers.
It is suggested that CD45RO+memory T cells may be most susceptible to the effects of lead on T cell subpopulations.
Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Immunopathologie, Lymphocyte T, Lymphocyte B, Sous population cellulaire, Antigène CD45RO
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Immunopathology, T-Lymphocyte, B-Lymphocyte, Cell subpopulation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0166971
Code Inist : 002B03L05. Création : 21/07/1998.