Objectives-To extend the follow up of a cohort of 14 457 aircraft maintenance workers to the end of 1990 to evaluate cancer risks from potential exposure to trichloroethylene and other chemicals.
Methods-The cohort comprised civilians employed for at least one year between 1952 and 1956, of whom 5727 had died by 31 December 1990.
Analyses compared the mortality of the cohort with the general population of Utah and the mortality and cancer incidence of exposed workers with those unexposed to chemicals, while adjusting for age, sex, and calendar time.
In the combined follow up period (1952-90), mortality from all causes and all cancer was close to expected (standardised mortality ratios (SMRs) 97 and 96, respectively).
Significant excesses occurred for ischaemic heart disease (SMR 108), asthma (SMR 160), and cancer of the bone (SMR 227), whereas significant deficits occurred for cerebrovascular disease (SMR 88), accidents (SMR 70), and cancer of the central nervous system (SMR 64).
Workers exposed to trichloroethylene showed non-significant excesses for non-Hodgkin's lymphoma (relative risk (RR) 2.0), and cancers of the oesophagus (RR 5.6), colon (RR 1.4), primary liver (RR 1.7), breast (RR 1.8), cervix (RR 1.8), kidney (RR 1.6), and bone (RR 2.1).
None of these cancers showed an exposure-response gradient and RRs among workers exposed to other chemicals but not trichlorethylene often had RRs as large as workers exposed to trichloroethylene. (...)
Mots-clés Pascal : Ethylène(trichloro), Solvant organique, Industrie aéronautique, Traitement entretien, Exposition professionnelle, Médecine travail, Homme, Toxicité, Mortalité, Epidémiologie, Etude longitudinale, Tumeur maligne, Mécanicien
Mots-clés Pascal anglais : Ethylene(trichloro), Organic solvent, Aeronautic industry, Maintenance treatment, Occupational exposure, Occupational medicine, Human, Toxicity, Mortality, Epidemiology, Follow up study, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0163548
Code Inist : 002B03L04. Création : 21/07/1998.