Objectives-To examine the causes of death among 1130 former workers of a plant in Tyler, Texas dedicated to the manufacture of asbestos pipe insulation materials.
This cohort is important and unusual because it used amosite as the only asbestiform mineral in the production process.
High level exposure of such a specific type was documented through industrial hygiene surveys in the plant.
Methods-Deaths were ascertained through various sources including data tapes from the Texas Department of Health and the national death index files.
As many death certificates as possible were secured (304/315) and cause of death assigned.
After select exclusions, 222 death certificates were used in the analysis.
Causes of death were compared with age, race, and sex specific mortalities for the United States population with a commercial software package (OCMAP Version 2.0).
There was an excess of deaths from respiratory cancer including the bronchus, trachea, and lung (standardised mortality ratio (SMR) 277 with 95% confidence interval (95% CI) 193 to 385).
Four pleural mesotheliomas and two peritoneal mesotheliomas were identified.
The analysis also showed an increasing risk of respiratory malignancy with increased duration of exposure including a significant excess of total deaths from respiratory cancer with less than six months of work at the plant (SMR 268 with 95% CI 172 to 399). (...)
Mots-clés Pascal : Amiante, Fibre minérale, Toxicité retardée, Exposition professionnelle, Médecine travail, Antécédent, Mortalité, Epidémiologie, Etude cohorte, Texas, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Mésothéliome, Homme, Amosite, Histoire professionnelle
Mots-clés Pascal anglais : Asbestos, Mineral fiber, Delayed toxicity, Occupational exposure, Occupational medicine, Antecedent, Mortality, Epidemiology, Cohort study, Texas, United States, North America, America, Malignant tumor, Mesothelioma, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0163547
Code Inist : 002B03L03. Création : 21/07/1998.