Pineal tumors : Experience with 48 cases over 10 years.
KSPN-JSPN Joint Symposium "Pineal Region Tumors in the Far East : the Specific Clinical Aspects". Kurume Fukuoka, JPN, 1997/05.
The authors retrospectively reviewed 48 patients treated at Seoul National University Hospital (SNUH) between 1986 and 1995.
There were 35 children and 13 adults, accounting for 10.1% of 345 pediatric and 0.68% of 1914 adult brain tumors in SNUH during the same period.
The 48 cases consisted of 33 cases of germ cell tumor (69%, GCT) ; 6 of pineoblastoma (PB, 12.5%) ; 3 of pineocytoma (PC, 6.3%) ; 3 of anaplastic astrocytoma (6.3%) ; 1 of astrocytoma ; 1 of glioblastoma ; and 1 of ependymoma.
The median age was 13 years (range 1-59) and the male-to-female ratio was 3.36 : 1. The most frequent presenting symptom was due to increased intracranial pressure (90%), followed by Parinaud syndrome or diplopia (50%). Patients with a benign tumor, such as teratoma (TE), astrocytoma, or ependymoma, underwent surgery by the occipital transtentorial approach (OTT) for attempted radical resection without adjuvant therapy, while patients with immature teratoma (imTE), PC, and anaplastic astrocytoma underwent regional radiotherapy (RT) after debulking via OTT.
Seven patients with nongerminomatous malignant GCT (NG-MGCT) and 3 with germinoma (GE) underwent craniospinal radiation only, 6 with GE, a NG-MGCT, and 2 with GE+TE received craniospinal radiotherapy (CSRT) after debulking via OTT.
Three patients with GE, 4 with NG-MGCT, and 3 with PB underwent radiochemotherapy after debulking via OTT.
Forty-four patients were followed up after treatment. (...)
Mots-clés Pascal : Tumeur germinale, Epiphyse, Corée, Asie, Type histologique, Traitement, Epidémiologie, Incidence, Pronostic, Enfant, Homme, Adulte, Endocrinopathie, Epiphyse pathologie, Tumeur maligne
Mots-clés Pascal anglais : Germ cell tumor, Pineal body, Korea, Asia, Histological type, Treatment, Epidemiology, Incidence, Prognosis, Child, Human, Adult, Endocrinopathy, Pineal diseases, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0155482
Code Inist : 002B21A02. Création : 21/07/1998.