Role of Helicobacter pylori infection in perforation of peptic ulcer : An ageand gender-matched case-control study.
Taisho International Symposium on Gastroenterology. Shimoda, JPN, 1996/04/23.
Evidence showed a marked decrease in recurrence rate of peptic ulcer after eradication of Helicobacter pylori infection.
However, whether H. pylori infection is etiologically related to perforation of peptic ulcer remains to be clarified.
We therefore conducted an age-and gender-matched case-control study between perforated and nonsurgical peptic ulcers in H. pylori infection and examined differences in the cytotoxin genes cagA and vacA.
Serum H. pylori IgG antibody (ELISA) was positive in 20/21 (95%) of perforated vs. 37/40 (93%) of nonsurgical duodenal ulcers and in 5/5 (100%) of perforated vs. 24/28 (86%) of nonsurgical gastric ulcer patients.
Positivity of H. pylori DNA in gastric juice, which was amplified by PCR and identified by Southern blot hybridization, was 17/23 (74%) of perforated vs. 32/45 (71%) in the nonsurgical duodenal ulcer group.
Positivity of the cytotoxin genes cagA and vacA in H. pylori DNA-positive gastric juice was as follows :
perforated vs. nonsurgical duodenal ulcer, cagA 11/13 (85%) vs. 24/27 (89%) ;
vacA1 : 9/13 (69%) vs. 22/27 (82%) ;
vacA2 8/13 (62%) vs. 21/27 (78%). There were no significant differences between the perforated and nonsurgical peptic ulcer groups for these H. pylori serum and gene markers.
It is assumed that H. pylori infection is not etiologically related to perforation of peptic ulcer.
Mots-clés Pascal : Ulcère, Gastroduodénal, Complication, Perforation, Estomac, Relation, Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Age, Sexe, Etude statistique, Homme, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie
Mots-clés Pascal anglais : Ulcer, Gastroduodenal, Complication, Perforation, Stomach, Relation, Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Age, Sex, Statistical study, Human, Digestive diseases, Gastric disease, Intestinal disease
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Cote : 98-0155194
Code Inist : 002B13B03. Création : 21/07/1998.