Transmission of Hepatitis C virus : A study of the main risk factors in a sicilian population of volunteer blood donors.
The Hepatitis C virus (HCV) is quite widespread in Sicily, and in the absence of a vaccine, prophylaxis is important.
In order to determine the most effective means ofprophylaxis, we must first understand the main vectors of transmission.
We performed a case control study on 274 consecutive anti-HCV virus positive subjects and compared them with 548 anti-HCV negative subjects, matched for sex and age and selected from voluntary blood donors.
The modes of transmission were investigated by means ofa detailed questionnaire focused on the common risk factors ofHCV contagion.
Univariate analysis showed associations between HCV infection and transfusions (OR 23.0), surgery (OR 2.2), family history of chronic liver disease (OR 4.54), and drug addiction (OR 5. 74).
Multiple logistic regression indicated that transfusions (p<0.0001), surgery (p<0.002), family history (p<0.0001), drug addiction (p<0.002) and alcohol consumption (p<0.002) are related to the development ofHCV infection.
The modes of transmission of HCV in an endemic area of Sicily do not greatly differ from those in other Italian regions ; the subjects at greatest risk were those who had received blood transfusions or underwent surgery, alcoholics, drug abusers and those with a family history of chronic liver disease, who are probably more exposed to contracting the infection by non-conventional ways of transmission.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Transmission, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Facteur risque, Transfusion, Chirurgie, Toxicomanie, Epidémiologie, Homme, Sicile, Italie, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Transmission, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Risk factor, Transfusion, Surgery, Drug addiction, Epidemiology, Human, Sicily, Italy, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0155075
Code Inist : 002B30A01A2. Création : 21/07/1998.