Hepatitis C virus genotypes : epidemiological and clinical associations.
In a cohort of 292 chronic hepatitis C patients living in the Benelux countries the relationship between viral genotype and geographical origin, route of transmission, clinical characteristics and severity of liver disease was analyzed.
HCV-RNA isolates could be classified by the Line Probe Assay (LiPA) as 1a, 1b, 2,3,4 or 5 in 286 (98%) cases.
Patients of European origin were predominantly infected with HCV sub-type 1b (164/254,65%, CI 58-70%), as were patients of Asian origin (7/13,54%). Patients originating from Surinam (South America) had predominantly type 2 (9/10,90%), whereas Africans were mainly infected with type 4 (7/9,77%). Blood transfusion was the mode of transmission in 142 (50%) patients, intravenous drug abuse (IVDA) in 40 (14%), occupational needle accident or tattoo in 11 (4%) ; no obvious source of infection was found in 93 (33%). In patients infected by blood transfusion, subtype 1b was predominant (70%, CI 61-77%), whereas subtypes la and 3 were predominant in those infected by IVDA (25% and 45%, respectively, p<0.001).
Cirrhosis was observed in 68 (24%) patients ; in multivariate analysis, factors independently related to cirrhosis were : the duration of infection, age and prior hepatitis B. No significant relationship was found between the severity of fibrosis or liver inflammation and the HCV (sub) types. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Relation incertitude, Génotype, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Symptomatologie, Répartition géographique, Contamination, Indice gravité, Epidémiologie, Homme, Bénélux, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Uncertainty relation, Genotype, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Symptomatology, Geographic distribution, Contamination, Severity score, Epidemiology, Human, Benelux, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0154970
Code Inist : 002B05C02G. Création : 21/07/1998.