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  1. Fulltext. Vitamin K prophylaxis in less developed countries : Policy issues and relevance to breastfeeding promotion.

    Article - En anglais


    Vitamin K prophylaxis prevents hemorrhagic disease of the newborn.

    The present review estimates the potential magnitude of this problem in less developed countries, assessing the need for prophylaxis, along with its cost-effectiveness and feasibility.

    Late hemorrhagic disease, occurring between 2 and 12 weeks, often leads to death or permanent disability.

    Its median incidence in developed countries is 7 per 100 000 births.

    Incidences in less developed countries may be much higher.

    Three incidence scenarios are proposed and the corresponding losses of disability-adjusted life-years (DALYs) calculated.

    Under the intermediate scenario, late hemorrhagic disease accounts for 0.10% to 0.2% of DALYs lost to children less than 5 years of age.

    Assuming a cost of $1.00 per injection, each DALY saved would, cost $133.

    Decisions on prophylaxis must be made on a national basis, considering mortality levels and causes, health budgets, and feasibility.

    Comparison with the impact of diseases prevented by breast-feeding shows that concern with hemorrhagic disease should not affect breast-feeding promotion efforts, although strategies for supplementing breast-fed infants must be explored.

    Mots-clés Pascal : Hémorragie, Déficit, Vitamine K, Chimiothérapie, Traitement, Allaitement, Pays en développement, Prévention, Incidence, Facteur risque, Nouveau né, Homme, Etude comparative, Analyse coût efficacité, Economie santé, Politique sanitaire

    Mots-clés Pascal anglais : Hemorrhage, Deficiency, Vitamin K, Chemotherapy, Treatment, Breast feeding, Developing countries, Prevention, Incidence, Risk factor, Newborn, Human, Comparative study, Cost efficiency analysis, Health economy, Health policy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0150596

    Code Inist : 002B02G. Création : 21/07/1998.