Context. - Clestra, a nonabsorbable, energy-free fat substitute used in snack foods, has been anecdotally reported to cause gastrointestinal (GI) adverse events, although such effects were not expected based on results from randomized trials, in which it was consumed in typical snack patterns.
- To determine whether ad libitum consumption of potato chips made with the fat substitute olestra results in a different level of Gl symptoms than regular chips made with triglyceride (TG).
- Randomized, double-blind, parallel, placebo-controlled trial.
- A suburban Chicago, III, multiplex cinema.
- A total of 1123 volunteers aged 13 to 88 years.
- Subjects were given a beverage and an unlabeled, white 369-g (13-oz) bag of potato chips made with olestra or TG during a free movie screening.
- Total and specific GI symptoms reported during a telephone interview conducted from 40 hours to 10 days after ingestion ; level of potato chip consumption ; and satiety level.
- Of 563 evaluable subjects in the olestra chip group, 89 (15.8%) reported 1 or more Gl symptoms, while 93 (17.6%) of the 529 evaluable subjects in the regular TG chip group did so (difference in symptom frequency between olestra and TG, - 1.8 ; 95% confidence interval, - 6.2 to 2.7 ; P=47).
For specific GI symptoms (eg, gas, diarrhea, abdominal cramping), there were no significant differences between olestra and TG chips. (...)
Mots-clés Pascal : Triglycéride, Pomme de terre chips, Substitut, Matière grasse, Trouble fonctionnel, Gastrointestinal, Alimentation, Toxicité, Homme, Olestra
Mots-clés Pascal anglais : Triglyceride, Potato chips, Substitute, Fat, Dysfunction, Gastrointestinal, Feeding, Toxicity, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0150373
Code Inist : 002B30A02A. Création : 21/07/1998.