Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses'Health study.
Environmental exposure to carcinogens may contribute to increasing breast cancer rates and geographic variation in breast cancer incidence in the United States.
One class of chemicals that has received much attention are the polyaromatic hydrocarbons that are ubiquitous in the environment and occur in cigarette smoke.
The cytochrome P450 1A1 (CYPIAI) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons.
Genotypic variants of CYPIAI have been associated with increased aryl hydrocarbon hydroxylase activity, and some epidemiological studies suggest that women with the variant genotype (s) are at increased risk for breast cancer.
We prospectively evaluated the associations between the CYPIAI polymorphisms and breast cancer risk, as well as the potential modification of these associations by cigarette smoking, in a case-control study nested within the Nurses'Health Study.
We analyzed the T-C transition at nucleotide 6235 (Mspl) and the A-G transition at nucleotide 4889 (exon 7) in CYPIAI by PCR-RFLP assays among 466 incident breast cancer cases and 466 matched controls.
Relative risks (RRs) and 95% confidence intervals (CIs) were used to quantify the risk of breast cancer among subjects who had at least one variant allele relative to subjects who were homozygous for the wild-type allele, using conditional logistic regression. (...)
Mots-clés Pascal : Tabagisme, Cytochrome P450, Polymorphisme, Tumeur maligne, Glande mammaire, Expression génique, Produit gène, Homme, Femelle, Facteur risque, Génotype, Etude cas témoin, Caucasoïde, Infirmier, Glande mammaire pathologie, Sang, Liquide biologique, Cytochrome CYP1A1
Mots-clés Pascal anglais : Tobacco smoking, Cytochrome P450, Polymorphism, Malignant tumor, Mammary gland, Gene expression, Gene product, Human, Female, Risk factor, Genotype, Case control study, Caucasoid, Nurse, Mammary gland diseases, Blood, Biological fluid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0150217
Code Inist : 002B30A01A2. Création : 21/07/1998.