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  1. Environmental and biological monitoring of exposure to mancozeb, ethylenethiourea, and dimethoate during industrial formulation.

    Article - En anglais

    The results of environmental (11 subjects) and biological (57 subjects) monitoring of exposure to mancozeb, ethylenethiourea (ETU), and dimethoate are reported for employees of a firm producing commercial formulations containing these active ingredients.

    Urinary excretion (GM (GSD)) of ETU (mug/g creatinine) and alkylphosphates [dimethylphosphate (DMP)+dimethylthiophosphate (DMTP)+dimethyldithiophosphate (DMDTP)) (nmol/g creatinine) was 65.3 (4.8) and 419.2 (2.1), respectively, for employees engaged in the formulation of a product containing 80% mancozeb (n=9), 36.6 (1.9) and 296.4 (2.4) for those formulating a product containing 35% mancozeb (n=9), 9.5 (6.1) and 1022.4 (3.0) for those engaged in plant maintenance and internal transport of materials (n=6), 10.3 (4.2) and 322.8 (3.3) for those engaged in packaging the mancozeb formulations (n=16), 4.4 (3.3) and 2545.4 (3.9) for those formulating a product containing 40% dimethoate (n=11), and 3.0 (2.7) and 871.7 (3.3) for those bottling the same dimethoate formulation (n=10).

    Air concentrations (mug/m3) ranged from 25.3 to 194.4 for dimethoate, from 0.2 to 1.3 for ETU, and from 139.9 to 949.0 for mancozeb.

    Urinary excretion of ETU and alkylphosphates showed a significant correlation with mancozeb (r2=971), and ETU (r2=858), and dimethoate (r2=955) contamination of the hands. (...)

    Mots-clés Pascal : Toxicité, Pesticide, Fongicide, Carbamate, Dithiocarbamate organique, Exposition professionnelle, Médecine travail, Formulation, Industrie chimique, Appareil respiratoire pathologie, Peau pathologie, Analyse quantitative, Liquide biologique, Urine, Analyse statistique, Analyse régression, Dimethoate, Organophosphoré, Thiourées, Mancozeb, Imidazolidine-2-thione

    Mots-clés Pascal anglais : Toxicity, Pesticides, Fungicide, Carbamate, Organic dithiocarbamate, Occupational exposure, Occupational medicine, Formulation, Chemical industry, Respiratory disease, Skin disease, Quantitative analysis, Biological fluid, Urine, Statistical analysis, Regression analysis, Dimethoate, Organophosphorus compounds, Thioureas

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0150005

    Code Inist : 002B30B01A. Création : 21/07/1998.