Epidemiologic studies have suggested that cigarette smoking is a risk factor for the development of hepatocellular carcinoma (HCC).
To further investigate this relation, the authors measured levels of 4-aminobiphenyl-DNA adducts by an immunoperoxidase method in surgical liver tissues obtained between 1984 and 1995 from 105 Taiwanese patients with histologically confirmed HCC and 37 Taiwanese patients with metastatic liver tumors or intrahepatic stones.
Information on clinicopathologic characteristics, cigarette smoking, and alcohol drinking was abstracted from hospital charts.
Mean relative staining intensity for 4-aminobiphenyl-DNA was slightly higher in tumor tissues than in nontumor tissues obtained from HCC patients.
Both mean intensities were significantly higher than the mean intensity of control tissues taken from non-HCC patients.
However, no difference in mean relative staining intensity was found between smokers and nonsmokers in tissues obtained from non-HCC patients, or in tumor or nontumor tissues taken from HCC cases.
After stratification of the relative staining intensities of 4-aminobiphenyl-DNA adduct levels into tertiles according to the total numbers of control tissues analyzed, there was a monotonically increasing risk of HCC.
Odds ratios were 4.14 (95% confidence interval (Cl) 1.1 5-15.50) and 9.71 (95% Cl 2.82-34.86) for medium and high adduct levels compared with low adduct levels, respectively. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Tabagisme, Diphenylamine, DNA, Epidémiologie, Facteur risque, Homme, Toxicité, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Tobacco smoking, Diphenylamine, DNA, Epidemiology, Risk factor, Human, Toxicity, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0149859
Code Inist : 002B03E. Création : 21/07/1998.