This preliminary study was designed in a trial to delineate the size of the problem ofochratoxicosis and its relation to genesis of lesions mounting to end stage renal disease (ESRD) or urothelial tumors in Egypt.
This study comprised five groups of patients having renal diseases of different presentations ; they are : patients with (ESRD) under conservative medical treatment (group 1), patients with (ESRD) under treatment with regular hemodialysis (group 2), renal allograft recipients (group 3), patients with nephrotic syndrome (group 4) and patients with urothelial tumors (group 5).
In addition, two reference groups : potential related donors for renal transplantation (group 6) and healthy control with negative family history of renal disease (group 7).
For all groups, laboratory, radiological and histopathological evaluation of kidney status were carried out coupled with determination of ochratoxin A level in serum, in urine and in biopsy specimens of patients with urothelial tumors.
High ochratoxin serum levels were found in patients with ESRD (groups 1 and 2) (P<0.01), higher serum levels were detected in the group without dialysis (group 1) in comparison with the reference groups possibly due to ochratoxin.
A clearance by dialysis.
Ochratoxin A was detected in serum and urine of renal transplant recipients (group 3) (P<0.01) and especially higher levels were found in patients with nephrotic syndrome (group 4) (P<0.001). (...)
Mots-clés Pascal : Ochratoxine, Mycotoxine, Toxicité, Ochratoxicose, Homme, Egypte, Afrique, Appareil urinaire pathologie, Insuffisance rénale, Tumeur maligne, Rein, Epidémiologie
Mots-clés Pascal anglais : Ochratoxin, Mycotoxin, Toxicity, Ochratoxicosis, Human, Egypt, Africa, Urinary system disease, Renal failure, Malignant tumor, Kidney, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0149386
Code Inist : 002B03J. Création : 21/07/1998.