The production of mutations in cellular tumor suppressor genes such as p53 is involved in the development of many human cancers.
These mutations result in the expression of mutant forms of the encoded p53 protein which can potentially serve as a biomarker for this carcinogenic process.
Workers exposed to vinyl chloride who are at risk for the development of the sentinel neoplasm angiosarcoma of the liver represent a model population for the study of such a mutant p53 biomarker, since vinyl chloride is known to cause specific p53 mutations in persons with angiosarcoma of the liver.
To determine the relation between vinyl chloride exposure and this p53 biomarker, the authors examined serum samples collected between 1987 and 1992 from a cohort of 225 French vinyl chloride workers and 111 unexposed controls (matched according to age, sex, race, smoking, and alcohol drinking) for the presence of mutant p53 protein, using an enzyme-linked immunosorbent assay.
Stratification of the exposed workers by quartile of vinyl chloride exposure (in estimated ppm-years) yielded a statistically significant trend of increasing odds ratios for p53 biomarker seropositivity with increasing exposure.
These results suggest that this serum biomarker for mutant p53 protein is related to vinyl chloride exposure and may be an early indicator of carcinogenic risk in exposed individuals.
Mots-clés Pascal : Mutation, Protéine p53, Gène TP53, Gène suppresseur tumeur, Gène onc, Carcinogenèse, Angiosarcome, Foie, Exposition professionnelle, Activité professionnelle, Vinylique chlorure copolymère, Epidémiologie, Biologie moléculaire, Marqueur biologique, Homme, Médecine travail, Sarcome, Toxicité, France, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Tumeur maligne, Foie pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Mutation, p53 Protein, TP53 Gene, Tumor suppressor gene, Onc gene, Carcinogenesis, Angiosarcoma, Liver, Occupational exposure, Professional activity, Vinyl chloride copolymer, Epidemiology, Molecular biology, Biological marker, Human, Occupational medicine, Sarcoma, Toxicity, France, Europe, Cardiovascular disease, Vascular disease, Malignant tumor, Hepatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0149384
Code Inist : 002B03L06. Création : 21/07/1998.