The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals.
The reasons for the increase among immunocompetent patients are unclear.
The authors conducted a case-control study of PCNSL at the Mayo Clinic based on cases from local community and referral practices.
Cases were all PCNSL patients without immunodeficiency diagnosed between 1975 and 1994 (n=109).
Two groups of controls were selected from the same referral practice, namely, patients with other cancer (cancer controls ; n=101), and patients with a different neurologic disease (neurologic controls ; n=109) seen at our institution during the same time period.
PCNSL was significantly associated with lower education when cases were compared with cancer controls but only suggestively when cases were compared with neurologic controls.
PCNSL cases were less likely to have had a history of tonsillectomy or oral contraceptive use compared with both control groups.
The findings regarding autoimmune disorders and cardiovascular diseases were inconsistent for the two control groups.
Neither farming nor prior personal or family history of cancer appeared to be risk factors for PCNSL.
The findings of this study warrant further investigation of tonsillectomy and oral contraceptives as possible factors for PCNSL.
Mots-clés Pascal : Lymphome non hodgkinien, Système nerveux central, Facteur risque, Epidémiologie, Amygdalectomie, Contraceptif, Voie orale, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Système nerveux central pathologie, Système nerveux pathologie, Chirurgie
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Central nervous system, Risk factor, Epidemiology, Tonsillectomy, Contraceptive, Oral administration, United States, North America, America, Case control study, Human, Malignant hemopathy, Lymphoproliferative syndrome, Central nervous system disease, Nervous system diseases, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0148291
Code Inist : 002B19B. Création : 21/07/1998.