Elderly-onset rheumatoid arthritis and its association with HLA-DRB1 alleles in Japanese.
To assess the association between HLA-DRB1 and elderly-onset rheumatoid arthritis (RA) (EORA) in Japanese people, we analysed the HLA-DRBI antigen frequencies of EORA patients.
The age at onset distribution of 852 Japanese RA patients was analysed, and EORA was defined as an age at onset of 60 yr or older.
Among the 85 RA patients, 120 (14.1%) were EORA patients.
Their HLA-DRB1 antigen frequencies were assessed for significant deviation from those of the control (n=652) and adult-onset RA (AORA : disease onset between 16 and 59 yr ; n=732) groups.
The Japanese EORA patients were positively associated with DRB1*0101, *0405 and *1502, and the relative risks were 2.7,1.9 and 2.2, respectively.
The frequency of DRB1*1502 was also significantly higher among the EORA patients than in the AORA patients.
The EORA patients showed different trends from the AORA patients in their frequency of HLA-DRB1 alleles, which suggests that EORA may be a different subset from AORA in light of its imnunogenetic background.
Mots-clés Pascal : Polyarthrite rhumatoïde, Age apparition, Vieillard, Homme, Pathogénie, Déterminisme génétique, Système HLA-DR, Réaction chaîne polymérase, Technique associée, Exploration, Polymorphisme longueur fragment restriction, DNA, Japonais, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Biologie moléculaire, Génétique
Mots-clés Pascal anglais : Rheumatoid arthritis, Age of onset, Elderly, Human, Pathogenesis, Genetic determinism, HLA-DR-System, Polymerase chain reaction, Associated technique, Exploration, Restriction fragment length polymorphism, DNA, Japanese, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Molecular biology, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0144032
Code Inist : 002B15D. Création : 21/07/1998.