Controversy persists regarding primary sclerosing cholangitis (PSC) as a risk factor for colorectal carcinoma in patients with chronic ulcerative colitis.
Small sample size and differing endpoints have contributed to variation among reported studies.
This large case-control study was conducted to examine the possible association between PSC and colon carcinoma in patients with ulcerative colitis.
From Mayo Clinic records spanning 1976-1994,171 cases with both ulcerative colitis and colorectal carcinoma and 171 contemporaneous controls with ulcerative colitis but no colorectal neoplasia matched with regard to age, gender, extent, and duration of colitis were identified.
The diagnosis of PSC required cholangiographic confirmation.
Analysis employed a multivariate logistic regression model.
The prevalence of PSC was similar in cases (18%) and controls (15%) (P=0.54).
The adjusted odds ratio for colorectal carcinoma with PSC was 1.23 (95% confidence interval, 0.62-2.42).
Based on this large case-control study, there was no association between PSC and colorectal carcinoma in patients with ulcerative colitis.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Angiocholite sténosante, Rectocolite ulcérohémorragique, Chronique, Facteur risque, Epidémiologie, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Voie biliaire pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Sclerosing cholangitis, Ulcerative colitis, Chronic, Risk factor, Epidemiology, Case control study, United States, North America, America, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Biliary tract disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0143067
Code Inist : 002B13B01. Création : 21/07/1998.