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  1. Tobacco smoking and oestrogen replacement are associated with lower total and central fat in monozygotic twins.

    Article - En anglais

    BACKGROUND 

    The known postmenopausal increase in cardiovascular risk may relate in part to changes in fat distribution.

    Environmental factors which are known to influence cardiovascular disease risk may do so in part by influencing body fat and its distribution.

    OBJECTIVES 

    To determine the relationships between tobacco smoking, oestrogen replacement (ERT) and body fat and its distribution in postmenopausal women, independent of genetic factors, physical activity, diet composition and socioeconomic factors.

    DESIGN 

    Cross-sectional study in normal post menopausal twins.

    SUBJECTS 

    712 postmenopausal female twins (aged 58.7 ± o. 2y, body mass index (BMI) 24.4 ± 0.1 kg/m2).

    MEASUREMENTS 

    Anthropometry ; body composition and fat distribution by dual energy x-ray absorptiometry ; physical activity, muscle strength, socioeconomic status, dietary composition and dehydroepiandrosterone sulfate (DHEAS).

    RESULTS 

    In monozygotic pairs discordant for smoking, intrapair differences in total and central fat were greater than that in concordant pairs, with the lower fat mass in the smoking twin.

    Overall, smokers had a lower weight, BMI, total and central abdominal fat, despite a higher total and saturated dietary fat intake and similar DHEAS levels.

    The reduction in central fat was not independent of that in total fat. (...)

    Mots-clés Pascal : Préménopause, Composition corporelle, Masse grasse, Distribution, Jumeau monozygote, Etude comparative, Oestrogène, Traitement substitutif, Traitement, Tabagisme, Royaume Uni, Europe, Adulte, Homme, Femelle

    Mots-clés Pascal anglais : Premenopause, Body composition, Fat mass, Distribution, Monozygotic twin, Comparative study, Estrogen, Replacement therapy, Treatment, Tobacco smoking, United Kingdom, Europe, Adult, Human, Female

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0142963

    Code Inist : 002B30A01A2. Création : 21/07/1998.