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  1. Glutathione stransferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.

    Article - En anglais

    BACKGROUND

    Susceptibility to head and neck cancer in a particular individual may depend in part on the metabolic balance between Phase 1 enzymes, such as cytochromes P450 (CYPs), and Phase II enzymes, such as glutathione S-transferases (GSTs).

    Genetic variability in CYP and GST isoenzymes may contribute to individual differences in susceptibility to chemical carcinogenesis.

    GSTMI and GSTT1 null genotypes as well as polymorphic variants in the CYPIAI gene that may help determine the risk for head and neck cancer have been described in previous reports.

    METHODS

    Polymorphisms of GSTMI, GSTTI, and CYP1A1 in whole blood were detected by polymerase chain reaction (PCR) in 185 patients with head and neck squamous cell carcinoma (HNSCC), 78 patients with benign head and neck lesions (BHNL), and 207 blood donors.

    RESULTS

    GSTMI null genotype was demonstrated to be equally frequent in patients with HNSCC (50.8%), patients with BHNL (47.4%), and blood donors (51.7%). GSTTI null genotype occurred significantly more often in patients with BHNL. (33.3%) as compared with blood donors (20.3%), demonstrating that lack of GSTTI may be a risk factor for BHNL.

    Presence of the rare valine in the CYP1A1/Nco1 site was found in 33 patients with HNSCC (17.8%), in 20 patients with BHNL (25.6%), and in 34 blood donors (16.4%). The frequencies with which the presence of the rare cytosine nucleotide in the CYP1A1/Msp1 site was detected were 17.8%, 15.4%, and 15.9%, respectively.

    CONCLUSIONS

    (...)

    Mots-clés Pascal : Carcinome épidermoïde, Tête cou, Tumeur bénigne, Facteur risque, Epidémiologie, Variabilité génétique, Glutathione transferase, Transferases, Enzyme, Isozyme, Cytochrome P450, Polymorphisme, Gène, Marqueur tumoral, Pays Bas, Europe, Homme, Tumeur maligne, ORL pathologie, Génétique

    Mots-clés Pascal anglais : Squamous cell carcinoma, Head and neck, Benign neoplasm, Risk factor, Epidemiology, Genetic variability, Glutathione transferase, Transferases, Enzyme, Isozyme, Cytochrome P450, Polymorphism, Gene, Tumoral marker, Netherlands, Europe, Human, Malignant tumor, ENT disease, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0142588

    Code Inist : 002B10A01. Création : 21/07/1998.