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  1. Immunological effects of occupational exposure to metallic mercury in the population of T-cells and NK-cells.

    Article, Communication - En anglais

    Nordic Symposium on Trace Elements in Human Health and Disease. Roskilde, DNK, 1997/06/29.

    This paper presents a study of the counts of lymphocytes, (CD3+) T-cells, (CD4+) T-helper and (CD8+) T-suppressor and (CD16+) NK-cells in the peripheral blood of 101 males with a history of occupational exposure to metallic mercury vapours (Hg°) and in 36 males without this exposure.

    These workers were divided depending on the duration of exposure : 37 males with a short-term history of exposure to Hg0 (up to 10 years) and 64 males with a history of long-term exposure (10 to 37 years).

    For the determination of T-cell populations monoclonal antibodies were used in indirect immunofluorescence tests.

    The time weighted average of mercury concentrations in air was 0.028 mg m-3.

    Mercury concentration in the urine of the exposed subjects ranged from 20-260 mug dm-3, and in blood it was from 4 to 72 mug dm-3.

    Stimulation of the T-cell line was noted as evidenced by increased numbers of (CD3+) T-cells, (CD4+) T-helper and (CD8+) T-suppressor cells in the workers with<10 or>10 years'exposure to Hg0.

    Lower increase count of (CD3+) T-cells and (CD4+) T-helper cells than (CD8+) T-suppressor cells was the cause of decreased values in the (CD3+) T/ (CD8+) T-suppressor ratio and (CD4+) T-helper/ (CD8+) T-suppressor ratio in the workers with<10 or>10 years'of exposure.

    Moreover, no changes were observed in the T-cell populations between workers with<10 and those with>10 years'exposure. (...)

    Mots-clés Pascal : Mercure, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Cellule NK, Lymphocyte T, Inhalation, Vapeur, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Mercury, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Natural killer cell, T-Lymphocyte, Inhalation, Vapor, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0142558

    Code Inist : 002B03L05. Création : 21/07/1998.