OBJECTIVE Few data exist on the prevalence of hyperprolactinaemia in the community.
This study was intended to determine the prevalence of hyperprolactinaemia in a sample closely matched to the current British population aged 38 years and over.
DESIGN AND PATIENTS The 1877 survivors at the 20-year follow-up of the Whickham Survey were a cross-sectional sample of the community aged 38 years and over.
Serum was frozen and stored at - 30°C from 90% of the survivors (751 men, 924 women, median age 58 years (range 38 to 93 years)) who participated in the follow-up survey.
MEASUREMENTS Two years after the follow-up survey, serum prolactin concentrations were measured by ELISA/1 step sandwich assay (reference range ¾ 600 mU/l in men and women).
A repeat prolactin measurement was made In those subjects who had prolactin levels within the top 2.5% of men and women in this sample.
RESULTS At screening, 0.7% of the men and 2-5% of the women had serum prolactin levels greater than 600 mU/l. For men, 2.5% were above 400 mU/l. The prevalence of hyperprolactinaemia, if defined as greater than 400 mU/l in men and greater than 600 mU/l in women on repeat testing, was 1-4% in the men and 1-2% in the women.
The aetiology in men was prolactin-raising drugs (n=3), renal failure (n=1), microprolactinoma (n=1), and unknown (n=2), and in women it was prolactin-raising drugs (n=7), microprolactinoma (n=1), and unknown (n=1). (...)
Mots-clés Pascal : Hyperprolactinémie, Prévalence, Epidémiologie, Etude longitudinale, Thyroïde pathologie, Maladie autoimmune, Etiologie, Royaume Uni, Europe, Adulte, Homme, Prolactine, Endocrinopathie
Mots-clés Pascal anglais : Hyperprolactinemia, Prevalence, Epidemiology, Follow up study, Thyroid diseases, Autoimmune disease, Etiology, United Kingdom, Europe, Adult, Human, Prolactin, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0142259
Code Inist : 002B30A01A2. Création : 21/07/1998.