Influence of the transmission route and disease duration in the histopathology of chronic hepatitis C : a study of 101 patients.
Objective Different studies have demonstrated that factors such as transmission route, disease duration and age at the time of infection can influence the histological evolution of chronic hepatitis by the hepatitis C virus (HCV).
The aim of this study was to determine if epidemiological factors such as disease duration and transmission route influence the severity of the histological lesions of patients with chronic hepatitis by HCV.
Design A prospective study.
Methods The hepatic biopsies of 101 patients diagnosed with chronic hepatitis by HCV were studied.
The patients were divided into three groups according to transmission mode : (1) post-transfusional (n=28), (2) associated with the use of drugs by parenteral route or intravenous drug use (n=28), and (3) sporadic hepatitis (n=45).
Results We found more severe forms of hepatopathy in post-transfusional hepatitis and sporadic groups than in the intravenous drug user group of patients.
The disease evolution time was significantly higher in patients diagnosed as having chronic active hepatitis with or without cirrhosis (13.8 ± 9 years) than in patients with chronic persistent hepatitis (8 ± 4 years), P<0.01.
We found a significant correlation between the evolution time of the infection by HCV and the Histology Activity Index (P<0.01).
The multivariate analysis showed that only the transmission route and the disease evolution time are predictive variables of Histology Activity Index in chronic hepatitis C. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Chronique, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Relation incertitude, Mode transmission, Temps exposition, Indice gravité, Exploration cytologique, Grade histologique, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie, Anatomopathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Chronic, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Uncertainty relation, Transmission mode, Exposure time, Severity score, Cytologic investigation, Histological grading, Statistical study, Human, Digestive diseases, Hepatic disease, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0138448
Code Inist : 002B05C02G. Création : 21/07/1998.