Epidemiologic historical cohort studies of petroleum refinery and chemical manufacturing workers in Texas were reviewed to examine their cancer mortality in comparison to the U.S. and to assess the possible impact of cancer mortality among these workers on the State of Texas as a whole. standardized mortality ratios and 95% confidence intervals were calculated for 20 cancer types, taking into account the heterogeneity of individual studies.
There were 4314 cancer deaths among the 92,318 workers employed in 10 independent plant populations.
Overall, there was a significant deficit in cancer mortality among petrochemical workers compared with the general U.S. population (SMR=88,95% CI=80 to 96).
Only the summary SMRs for brain cancer (SMR=113,95% CI=96 to 133) and leukemias (SMR=112,95% CI=94 to 130) approached statistical significance.
Lung and liver cancer mortality excesses, noted for Texas as a whole, were decreased in these workers.
Additional follow-up of these cohorts, their expansion to include minority and female workers, and additional study of possible occupational contributions to leukemia and brain cancer are recommended.
Mots-clés Pascal : Industrie pétrochimique, Raffinerie, Exposition professionnelle, Médecine travail, Homme, Epidémiologie, Texas, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Mortalité, Industrie chimique, Carcinogène, Etude cohorte
Mots-clés Pascal anglais : Petrochemical industry, Refinery, Occupational exposure, Occupational medicine, Human, Epidemiology, Texas, United States, North America, America, Malignant tumor, Mortality, Chemical industry, Carcinogen, Cohort study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0138345
Code Inist : 002B04B. Création : 21/07/1998.