To determine the seroprevalence of herpes simplex virus type 2 (HSV-2), to identify correlates of infection, and to describe the correlation with human immunodeficiency virus (HIV) seropositivity, 224 HIV-negative and 191 HIV-positive male factory workers in Zimbabwe were screened for HSV-2-specific antibodies.
HSV-2 seroprevalence was 35.7% among HIV-negative subjects and 82.7% among HIV-positive subjects.
The weighted estimate of HSV-2 seroprevalence in this population is 44.6%. The correlation between HIV and HSV-2 remained significant after controlling for multiple sex partners, paying for sex, and history of sexually transmitted disease (adjusted odds ratio, 8.0 ; 95% confidence interval, 4.8-13.1).
If the association between HSV-2 and HIV is causal, then the high seroprevalence of HIV and HSV-2 suggests that suppressive HSV-2 treatment should be considered as a strategy to reduce HIV transmission in this population.
HSV-2 seroconversion may be a suitable surrogate end point to evaluate HIV prevention interventions.
Mots-clés Pascal : Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Herpesvirus hominis 2, Alphaherpesvirinae, Herpesviridae, Infection mixte, Homme, Epidémiologie, Zimbabwe, Afrique, Prévalence, Maladie sexuellement transmissible
Mots-clés Pascal anglais : Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Herpesvirus hominis 2, Alphaherpesvirinae, Herpesviridae, Mixed infection, Human, Epidemiology, Zimbabwe, Africa, Prevalence, Sexually transmitted disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0138099
Code Inist : 002B05C02D. Création : 21/07/1998.