Objective The prevalence of antibodies to CagA protein, associated with the risk of developing gastric cancer (GC), was studied in an Estonian adult population with a high prevalence of Helicobacter pylori (HP) infection and in a group of GC patients.
Design In a representative sample of a random adult population from the South Estonian town of Karksi-Nuia, containing 199 subjects (86 M, 113 F, mean age 42.4) and in 45 (22 M, 23 F, mean age 64.5) consecutive patients with gastric adenocarcinoma, recruited during the periods 1986-87 and 1995-96 in the Hospital of Oncology, University of Tartu, anti-CagA IgG antibodies were determined by enzyme-linked immunosorbent assay (ELISA) using a recombinant fragment of CagA protein.
The occurrence of anti-CagA IgG in ELISA was compared with immunoblot results for 141 subjects.
Results Seropositivity to acid glycine extracted cell surface proteins of HP was 85% in the population and 91% in GC patients (p=0.39).
Anti-CagA IgG antibodies were present in 63% of the population and in 87% of GC patients (p=0.004).
The highest prevalence of anti-CagA IgG in the population sample occurred in the age group 20-29 (76%). A comparison of anti-CagA positivity evaluated by using ELISA and immunoblot showed an agreement of results in 80% of cases.
Conclusion HP seropositivity was similarly high in the Estonian random adult population sample and in GC patients, however, the prevalence of anti-CagA IgG was significantly higher in GC patients. (...)
Mots-clés Pascal : Carcinome, Estomac, Relation incertitude, Facteur risque, Séropositivité, Incidence, Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Diagnostic, Etude statistique, Homme, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie, Gène CagA
Mots-clés Pascal anglais : Carcinoma, Stomach, Uncertainty relation, Risk factor, Seropositivity, Incidence, Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Diagnosis, Statistical study, Human, Malignant tumor, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0137418
Code Inist : 002B13B01. Création : 21/07/1998.