To analyze various quantitative measures of inflammatory activity and joint damage, including articular, radiographic, laboratory, questionnaire, and physical function measures, in regard to changes in status in surviving patients and prediction of mortality in non-survivors over 5 years in a cohort of patients with rheumatoid arthritis (RA) monitored in the mid-1980s and early 1990s.
A comprehensive evaluation, which included a complete joint count, radiograph, laboratory tests, physical measures of function, and self-report questionnaire scales, was performed at baseline and 5 years later in 210 consecutive patients with RA.
Five years after baseline, 206 of the 210 patients were accounted for : 37 had died, 130 had a comprehensive repeat assessment, and 39 had a more limited repeat assessment.
In surviving patients, most measures of activity were generally unchanged or somewhat better including joint tenderness, pain on motion, and swelling ; erythrocyte sedimentation rate and rheumatoid factor ; as well as questionnaire scores for pain, global status, helplessness, and difficulty in performing 8 activities of daily living (ADL) according to a modified Health Assessment Questionnaire (MHAQ).
By contrast, measures of damage, including joint deformity, grip strength, walk time, and radiographic scores, indicated worse status. (...)
Mots-clés Pascal : Polyarthrite rhumatoïde, Inflammation, Symptomatologie, Arthrite, Articulation, Analyse quantitative, Epidémiologie, Facteur prédictif, Evolutivité, Mortalité, Long terme, Morbidité, Pronostic, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Arthropathie
Mots-clés Pascal anglais : Rheumatoid arthritis, Inflammation, Symptomatology, Arthritis, Joint, Quantitative analysis, Epidemiology, Predictive factor, Evolutivity, Mortality, Long term, Morbidity, Prognosis, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Arthropathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0137129
Code Inist : 002B15D. Création : 21/07/1998.