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  1. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study.

    Article - En anglais

    Background and Purpose-We determined the relationship between apolipoprotein (Apo) E, MRI, and low cognitive scores.

    Methods-The relationship between age, education, ApoE genotype, MRI examination of the brain, subclinical and clinical cardiovascular disease, and low (<80) score on the Modified Mini-Mental State Examination (3MSE, as modified by Teng and Chui) was evaluated for 3469 black and white participants in the Cardiovascular Health Study (CHS) in years 5 and 6 of the study.

    The participants were followed for up to 3 years.


    The prevalence of scores<80 in years 5 and 6 of the CHS was 8.2% for participants without and 20.4% for those with prior history of stroke.

    Age, race, and education were important determinants of low 3MSE scores.

    The prevalence of ApoE-4 (odds ratio [OR], 1.6 [1.1 to 2.1]) was directly related to scores<80, as was high ventricular volume (OR, 1.6 [1.2 to 2.3]), high white matter grade (OR, 1.4 [1.1 to 1.9]), and infarctlike lesions (OR, 1.6 [1.2 to 2.1]) on the MRI in the multivariate analysis.

    A five-point or greater decline in scores over up to 3 years was more often observed for participants with low 3MSE scores at year 5, at older ages, with lower education, and experiencing incident stroke (OR, 3.6 [1.2 to 10.6]), ApoE-4 genotype (OR, 1.8 [1.4 to 2.3]), and with MRI findings of high ventricular volume (OR, 2.0 [1.5 to 2.7]), and infarctlike lesions (OR, 1.2 [0.9 to 1.5]). (...)

    Mots-clés Pascal : Accident cérébrovasculaire, Facteur risque, Relation incertitude, Age, Race, Niveau, Education, Taux concentration, Apolipoprotéine E, Imagerie RMN, Encéphale, Etude statistique, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Imagerie médicale

    Mots-clés Pascal anglais : Stroke, Risk factor, Uncertainty relation, Age, Race, Level, Education, Concentration factor, Apolipoprotein E, Nuclear magnetic resonance imaging, Brain (vertebrata), Statistical study, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Medical imagery

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0135686

    Code Inist : 002B17C. Création : 21/07/1998.