Background and Purpose-The purpose of the present study was to calculate the prevalence and relative risk of unruptured incidental intracranial aneurysms (IAs) among families with IA case(s) compared with the general population in one geographically defined area in East Finland and to identify the risk group that could benefit most from screening for IAs.
We compared these results with our earlier study results of familial IA (FIA) cases, with two or more known IA cases in the same family.
Methods-The study groups were collected from the catchment area of the University Hospital of Kuopio in East Finland.
The inclusion criteria were age 30 to 70 years and unruptured incidental IAs =3 mm.
Patients with previous subarachnoid hemorrhage or in whom a ruptured IA was found to be the cause of death were excluded from all study groups.
During routine forensic autopsies the circle of Willis was studied for IAs to estimate the number of IAs in the general population.
In the families with one known IA case and in FIA families, MR angiography was used as a preliminary screening method for IAs, followed by intra-arterial angiography to verify suspected IAs.
Study populations were age and sex adjusted for the statistical calculations.
The relative risk for IAs among first-degree relatives in FIA families was 4.2 (95% confidence interval, 2.2 to 8.0) and among first-degree relatives in families with only one affected family member was 1.8 (95% confidence interval, 0.7 to 4.8) (...)
Mots-clés Pascal : Anévrysme, Artère, Intracrânien, Maladie héréditaire, Incidence, Risque, Indication, Dépistage, Intérêt, Etude comparative, Homme, Finlande, Europe, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie
Mots-clés Pascal anglais : Aneurysm, Artery, Intracranial, Genetic disease, Incidence, Risk, Indication, Medical screening, Interest, Comparative study, Human, Finland, Europe, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Arterial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0135681
Code Inist : 002B17C. Création : 21/07/1998.