Frequency of renal diseases and clinical indications for renal biopsy in children (report of the Italian National Registry of Renal biopsies in children).
Children's renal biopsy data were gathered for 3 consecutive years (1992-1994) by the Group of Renal Immunopathology of the Italian Society of Pediatric Nephrology, which opened a paediatric section of the Italian Registry of Renal Biopsies.
The Registry recorded the histological diagnosis and the clinical data at renal biopsy of 432 children ¾15 years old (mean age 8.96±3.7 years).
The most common glomerulonephritis (GN) at renal biopsy was idiopathic IgAGN (18.8%) and the most frequent secondary GN was Henoch-Schönlein purpura (HSP) nephritis (11.6%). Minimal-change disease (MCD) accounted for 11.6%, focal and segmental sclerosis (FSG) 8.5%, mesangial proliferative GN (MPGN) 9.5%, membranoproliferative GN 5.5%, and thin-membrane disease 5%. Lupus nephritis was diagnosed in 5% and Alport's GN in 3.9% of the cases.
The annual incidence of primary GN in Italian children was 11.1 cases per million children population (p.m.c.p.), IgAN accounting for 3.1 cases, MCD 2.3, and HSP nephritis 1.9 cases p.m.c.p. respectively.
Italian children underwent renal biopsy because of isolated microscopic haematuria in 19.3% of the cases, non-nephrotic proteinuria with or without microscopic haematuria in 31.2%, and nephrotic-range proteinuria in 34.2%, less frequently (15.3%) because of acute or chronic renal failure.
Children with persistent isolated microscopic haematuria had most frequently IgAN (34.9%) or thin-membrane disease (25.3%) (...)
Mots-clés Pascal : Biopsie, Rein, Fréquence, Incidence, Rein pathologie, Hématurie, Protéinurie, Italie, Europe, Epidémiologie, Diagnostic, Enfant, Homme, Hémorragie, Anatomopathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Biopsy, Kidney, Frequency, Incidence, Kidney disease, Hematuria, Proteinuria, Italy, Europe, Epidemiology, Diagnosis, Child, Human, Hemorrhage, Pathology, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0135278
Code Inist : 002B25H. Création : 21/07/1998.