Assessment of quality of life in early stage HIV-infected persons : data from the AIDS Time-Oriented Health Outcome Study (ATHOS).
The development of new pharmaceutical interventions for persons with human immunodeficiency virus (HIV) infection has resulted in extended survival and a need for valid, reliable and responsive instruments to assess health-related QoL (HRQoL).
This paper reviews the reliability and validity of an HRQoL instrument, the AIDS Health Assessment Questionnaire (AIDS-HAQ), among persons participating in an observational database of HIV infection.
The AIDS-HAQ includes nine subscales : disability, energy, general health, pain, cognitive functioning, mental health, social functioning, health distress and symptoms.
Individuals complete the AID-HAQ quarterly.
Data are reported for 440 individuals entering the study with early HIV infection.
Fifty-nine progressed to symptomatic disease and 109 to AIDS after 1 year.
The subscales of the instrument resulted in high internal consistency reliability (range=0.79-0.88).
Concurrent validity data reflected the ability to distinguish between patients with increasing disease severity.
In all domains, except cognitive functioning, individuals who progressed to AIDS had significant decrements (p<0.01) in HRQoL compared whith symptomatic and asymptomatic patients.
Significant decrements (p<0.01) were observed for disability, general health, energy and symptoms for patients who progresssed to symptomatic disease from an asymtomatic status.
Individuals who had decreasing CD4+counts also had significant declines. (...)
Mots-clés Pascal : Société, Sociologie, Virus, Microorganisme, Organisme, Système vivant, Questionnaire, Méthodologie, Information, Santé, Validité, Epidémiologie, Méthode étude, Evaluation, Registre, Documentation, Qualité vie, Mode de vie, Virus immunodéficience humaine, Retroviridae, Technique mesure, Collecte donnée, Banque donnée, Stockage information
Mots-clés Pascal anglais : Society, Sociology, Virus, Microorganism, Organism, Living system, Questionnaire, Methodology, Information, Health, Validity, Epidemiology, Investigation method, Evaluation, Register, Documentation, Quality of life, Life habit, Human immunodeficiency virus, Retroviridae, Measurement technique, Data gathering, Databank, Information storage
Notice produite par :
ORS Auvergne - Observatoire Régional de la Santé d'Auvergne
Code Inist : 002B30A11. Création : 21/07/1998.