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  1. Discriminative aspects of two generic and two asthma-specific instruments : relation with symtoms, bronchodilator use and lung function in patients with mild asthma.

    Article - En anglais

    The objective of this study was to compare the two most frequently used asthma-specific quality of life (QOL) questionnaires and two generic QOL questionnaires with clinical data in order to establish their ability to discriminate in asthma severity, also referred to as cross-sectional construct validity.

    We conducted a multicentre, randomized, placebo-controlled study investigating the long-term effects of the long-acting Bêta2-agonist formoterol in asthma patients using inhaled corticosteroids and short-acting Bêta2-agonists.

    Before randomization, the peak expiratory flow (PEF) and use of Bêta2-agonists for relief of symtoms were recorded twice daily for 1 month.

    At the end of the run-in period, the forced expiratory volume in 1 s (FEF1), airway hyper-responsiveness (PC20 methacholine) and QOL were measured, using two asthma-specific questionnaires, the Asthma Quality of Life Questionnaire (AQLQ) and the Living with Asthma Quality of life Questionnaire (LWAQ), as well as two generic questionnaires, the Short Form 36 (SF-36) and the Psychological General Well Being (PGWB) index.

    The quality of life of the patients (n=110) was only mildly impaired.

    The mean symptom score was 3.6 on a scale of 0-21 and the mean FEV1 was 65% of that predicted.

    The correlations between the QOL parameters and objective measures of asthma severity, such as the FEV1, PEF and PC20, were low (0.01-0.37). (...)

    Mots-clés Pascal : Asthme, Appareil respiratoire pathologie, Maladie, Société, Sociologie, Questionnaire, Méthodologie, Etude comparative, Information, Bronchopneumopathie obstructive, Qualité vie, Mode de vie, Technique mesure

    Mots-clés Pascal anglais : Asthma, Respiratory disease, Disease, Society, Sociology, Questionnaire, Methodology, Comparative study, Information, Obstructive pulmonary disease, Quality of life, Life habit, Measurement technique

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    Observatoire Régional de la Santé Auvergne-Rhône-Alpes

    Code Inist : 002B30A11. Création : 21/07/1998.