The poly (ADP-ribose) polymerase (PADPRP) gene has been implicated in carcinogenesis through its role in DNA repair, replication and recombination.
A two-allele polymorphism in the chromosome 13 PADPRP pseudogene has been studied in several racial groups.
It has been suggested that the B allele, which results from a 193-bp deletion in the gene, predisposes to myeloma in Blacks.
We assessed the association between chromosome 13 PADPRP pseudogene genotype, mutagen sensitivity (a marker reflecting host DNA repair capability), cigarette smoking, and lung cancer risk in a minority lung cancer case-control study.
The chromosome 13 PADPRP pseudogene polymorphism was detected by polymerase chain reaction-based analysis.
Mutagen sensitivity was measured by an in vitro assay that quantified bleomycin-induced chromatid breaks in peripheral blood lymphocyte cultures.
We examined 121 cases (80 African-Americans and 41 Mexican-Americans) with previously untreated lung cancer and 171 matched controls.
Our results suggested that the distribution of the PADPRP pseudogene genotype frequencies was significantly different among African-American and Mexican-American controls (P<0.001).
The susceptibility genotype (i.e. at least one B allele) was found in 82.5% of African-American cases, 79.4% of African-American controls, 53.7% of Mexican-American cases, and 32.4% of Mexican-American controls.
The odds ratios (OR) and 95% confidence intervals for the PADPRP susceptibility genotypes were 2. (...)
Mots-clés Pascal : NAD+ ADP-ribosyltransferase, Pentosyltransferases, Glycosyltransferases, Transferases, Enzyme, Pseudogène, Fréquence génique, Tumeur maligne, Bronchopulmonaire, Tabagisme, Mutagène, Prédisposition, Génotype, Génétique population, Race, Noir américain, Latinoaméricain, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Etats Unis, Amérique du Nord, Amérique, Epidémiologie moléculaire, Gène PADPRP
Mots-clés Pascal anglais : NAD+ ADP-ribosyltransferase, Pentosyltransferases, Glycosyltransferases, Transferases, Enzyme, Pseudogene, Gene frequency, Malignant tumor, Bronchopulmonary, Tobacco smoking, Mutagen, Predisposition, Genotype, Population genetics, Race, Black American, Latinamerican, Human, Respiratory disease, Lung disease, Bronchus disease, United States, North America, America, Molecular epidemiology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0132225
Code Inist : 002B11A. Création : 22/06/1998.