A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT).
The cases involved nonfatal myocardial infarction or death from coronary heart disease.
Serum samples (n=734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and alpha-gamma-and total tocopherol.
The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms.
Among nonsmokers, the odds ratios (95% confidence intervals (Cl)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-gamma-and total tocopherol, respectively.
The equivalent odds ratios (95% Cl) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively.
This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction.
Mots-clés Pascal : Cardiopathie coronaire, Lipide, Antioxydant, Plasma sanguin, Caroténoïde, Rétinol, alpha-Tocophérol, Taux, Epidémiologie, Facteur risque, Incidence, Homme, Etude cohorte, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Lipids, Antioxidant, Blood plasma, Carotenoid, Retinol, alpha-Tocopherol, Rate, Epidemiology, Risk factor, Incidence, Human, Cohort study, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0129489
Code Inist : 002B12A03. Création : 22/06/1998.