Although obesity and insulin levels are generally associated in cross-sectional data, the temporal and causal nature of their association is not yet clear.
Increased obesity may have preceded increased insulin levels or vice versa.
The authors examined the temporal relations between fasting insulin blood levels and weight in longitudinal data from the ongoing Normative Aging Study.
Two insulin measurements from which a rate of change (deltainsulin) could be calculated were available from 376 non-diabetic male subjects (mean age=62.1 years).
Rates of change in weight could be calculated for the previous inter-examination period (deltaWeight1), the contemporaneous period (deltaWeight2), and the inter-examination period following the second insulin measurement (deltaWeight3). deltaWeight2 was a significant predictor (p=0.0005) of Alnsulin in multiple linear regression models that included control for potential confounders (body mass index, waist-to-hip ratio, antihypertensive and diuretic medication use, and age) and for correlation between the initial level and change in insulin (mean fasting insulin). deltaWeight1 was added to the model and was found not to be statistically significant (p=0.15).
When the model was stratified by age tertile, the regression coefficient on deltaWeight1 was - 0.44 (p=0.018) for the youngest stratum, - 0.06 (p=0.72) for the middle stratum, and 0.21 (p=0.19) for the oldest men. (...)
Mots-clés Pascal : Obésité, Insuline, Taux, Plasma sanguin, Diabète, Etude cohorte, Etude temporelle, Etiologie, Homme, Epidémiologie, Etat nutritionnel, Etats Unis, Amérique du Nord, Amérique, Trouble nutrition, Endocrinopathie
Mots-clés Pascal anglais : Obesity, Insulin, Rate, Blood plasma, Diabetes mellitus, Cohort study, Temporal study, Etiology, Human, Epidemiology, Nutritional status, United States, North America, America, Nutrition disorder, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0129488
Code Inist : 002B21E01A. Création : 22/06/1998.