Dioxin exposure and non-malignant health effects : a mortality study.
To investigate, in a population heavily exposed to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD), the possible unusual occurrence of diseases other than cancer.
Methods-Five year extension of the follow up of the cohort involved in the Seveso accident.
Soil measurements identified three exposure zones : (A) highest contamination, (B) substantial, and (R) low but higher than background contamination.
Blood TCDD measurements, although limited in number, confirmed zone exposure ranking.
The 15 year mortality in the exposed cohort was compared with that of a large population in the surrounding non-contaminated territory.
Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated with Poisson regression techniques.
The already noted increased occurrence of cardiovascular deaths was confirmed, in particular in zone A, among males for chronic ischaemic heart disease (five deaths, RR 3.0,95% CI 1.2 to 7.3), and among females for hypertensive disease (three deaths, RR 3.6,95% CI 1.2 to 11.4) and chronic rheumatic heart disease.
Novel findings were the increase of chronic obstructive pulmonary disease, most notably among males in zone A (four deaths, RR 3.7,95% CI 1.4 to 9.9) and females in zone B (seven deaths, RR 2.4,95% CI 1.1 to 5.1) ; and from diabetes, which was significantly increased in females in zone B (13 deaths, RR 1.9,95% CI 1.1 to 3.2). (...)
Mots-clés Pascal : Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Toxicité, Homme, Accident, Industrie, Population, Proximité, Epidémiologie, Mortalité, Symptomatologie, Italie, Europe, Etude longitudinale, Seveso
Mots-clés Pascal anglais : Toxicity, Human, Accident, Industry, Population, Proximity, Epidemiology, Mortality, Symptomatology, Italy, Europe, Follow up study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0129417
Code Inist : 002B03L06. Création : 22/06/1998.