Role of body mass index in the prediction of all cause mortality in over 62 000 men and women. The Italian RIFLE pooling project.
Study objective-To evaluate the relation of body mass index (BMI) to short-term mortality in a large Italian population sample.
Design-Within the Italian RIFLE pooling project, BMI was measured in 47 population samples made of 32 741 men and 30 305 women aged 20-69 years (young 20-44, mature 45-69).
Data on mortality were collected for the next six years.
Main outcome measures-Age adjusted death rates in quintile classes of BMI and Cox proportional hazards models with six year all causes mortality as end point, BMI as covariate and age, smoking, systolic blood pressure as possible confounders were computed.
Multivariate analysis was tested in all subjects and after the exclusion of smokers, early (first two years) deaths, and both categories.
The univariate analysis failed to demonstrate in all cases a U or inverse J shaped relation.
The Cox coefficients for the linear and quadratic terms of BMI proved significant for both young and mature women.
The minimum of the curve was located at 27.0 (24.0,30.0,95% confidence limits, CL) and 31.8 (25.5,38.2,95% CL) units of BMI, for young and mature women respectively.
Similar findings were obtained even when exclusion were performed.
No relation was found for young men while for mature adult men only the model for all subjects retained significant curvilinear relation (minimum 29.3 ; 22.4,36.2,95% CL). (...)
Mots-clés Pascal : Mortalité, Court terme, Indice masse corporelle, Poids corporel, Epidémiologie, Facteur risque, Homme, Italie, Europe
Mots-clés Pascal anglais : Mortality, Short term, Body mass index, Body weight, Epidemiology, Risk factor, Human, Italy, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0128588
Code Inist : 002B30A01A2. Création : 22/06/1998.