Influence of biological and analytical variation on urine measurements for monitoring exposure to cadmium.
To define the mean intraindividual biological variation in urinary concentrations of cadmium and retinol binding protein (RBP) in untimed, random urine samples and the influence of creatinine or specific gravity correction on reducing this variation.
The relation between biological variation and analytical variation in defining uncertainty in a single measurement and significant differences between successive measurements was explored.
Methods-Repeat measurement study in subjects with either high historical exposure to cadmium but without current exposure, or unexposed volunteers.
Standard statistical tools used in clinical laboratory medicine were applied to define intraindividual biological and analytical variation.
Results and conclusion-Both creatinine and specific gravity correction of urinary cadmium measurements in random urine samples seem to reduce the intraindividual variability compared with uncorrected values.
With a standard definition, acceptable long term analytical precision for measurements of cadmium and RBP combined with creatinine analyses should be<9% and<15% respectively.
The mean intraindividual biological variation of cadmium and RBP, expressed as creatinine corrected, was 18% and 40% respectively in the subjects exposed to cadmium.
With the analytical precision used, significant differences (p<0. (...)
Mots-clés Pascal : Cadmium, Métal lourd, Exposition professionnelle, Médecine travail, Surveillance biologique, Homme, Comparaison intraindividuelle, Urine, Liquide biologique, Protéine liaison, Rétinol, Analyse quantitative, Marqueur biologique
Mots-clés Pascal anglais : Cadmium, Heavy metal, Occupational exposure, Occupational medicine, Biological monitoring, Human, Intraindividual comparison, Urine, Biological fluid, Binding protein, Retinol, Quantitative analysis, Biological marker
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0128383
Code Inist : 002B03L05. Création : 22/06/1998.