Increased rate of fractures and severe kyphosis : Sequelae of living into adulthood with cystic fibrosis.
Osteoporosis occurs in patients with cystic fibrosis as they age, but its clinical implications are not well defined.
To determine the clinical effect of decreased bone mineral density in adults with cystic fibrosis and to assess possible clinical predictors of osteoporosis.
Retrospective cohort study.
Academic cystic fibrosis center.
70 adults with late-stage cystic fibrosis who were referred for lung transplantation.
Bone mineral density was measured with dual-energy x-ray absorptiometry, patient-reported fracture events were confirmed by radiography, and kyphosis angles were measured by using the Cobb method.
Mean bone mineral densities for the spine, femur, and total body were severely depressed in patients with cystic fibrosis, averaging 2 SDs below those of age-matched normal controls (P<0.001).
Patient interviews showed that 54 fractures had occurred over 1410 patient-years, and chest radiographs showed evidence of 14 additional rib and 62 additional vertebral compression fractures.
The database (which covered 1410 patient-years) showed that fracture rates were approximately twofold greater in women with cystic fibrosis aged 16 to 34 years (P=0.015) and men with cystic fibrosis aged 25 to 45 years (P=0.04) than in the general population.
Vertebral compression and rib fractures were 100-and 10-fold more common than expected, respectively (P<0.001 for both comparisons). (...)
Mots-clés Pascal : Mucoviscidose, Ostéoporose, Fracture, Cyphose, Densitométrie, Epidémiologie, Complication, Prévalence, Physiopathologie, Homme, Rétrospective, Rachis dorsal, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire, Métabolisme pathologie, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme, Rachis pathologie, Déformation
Mots-clés Pascal anglais : Cystic fibrosis, Osteoporosis, Fracture, Kyphosis, Densitometry, Epidemiology, Complication, Prevalence, Pathophysiology, Human, Retrospective, Dorsal spine, United States, North America, America, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease, Metabolic diseases, Diseases of the osteoarticular system, Bone disease, Trauma, Spine disease, Deformation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0127575
Code Inist : 002B15I. Création : 22/06/1998.