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  1. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.

    Article - En anglais

    An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza.

    Serologic analysis indicated the presence of an H5 hemagglutinin.

    All eight RNA segments were derived from an avian influenza A virus.

    The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses.

    The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens.

    These results may have implications for global influenza surveillance and planning for pandemic influenza.

    Mots-clés Pascal : Influenzavirus aviaire, Influenzavirus A, Orthomyxoviridae, Virus, Isolat clinique, Virose, Infection, Enfant, Homme, Hong Kong, Chine, Asie, Appareil respiratoire pathologie, Mortalité, Pouvoir pathogène, Pathologie expérimentale, Poulet, Aves, Vertebrata, Caractérisation, Grippe A, Epidémiologie

    Mots-clés Pascal anglais : Avian influenzavirus, Influenzavirus A, Orthomyxoviridae, Virus, Clinical isolate, Viral disease, Infection, Child, Human, Hong Kong, China, Asia, Respiratory disease, Mortality, Pathogenicity, Experimental disease, Chicken, Aves, Vertebrata, Characterization, Influenza A, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0124277

    Code Inist : 002B05C02C. Création : 22/06/1998.