Objective The shortage of cobalt (Co) on the metal market forced the industry to add nickel (Ni) to Co as a binding agent for the sintering of hard metal.
This change enabled us to study (1) the exposure to Ni powder and (2) the effect of Ni on Co uptake (and vice versa).
Methods Equal amounts of Co and Ni were used in the mixture in a plant employing 50 workers.
Both personal ambient-air samples and single-void urine samples were taken twice in the same week, i. e, on Monday and Thursday.
Atomic absorption spectroscopy (AAS) was used for analyses.
Results The airborne availability of Ni (mean value 41.65 ± 6.29 mug/m3) was 2-fold that of Co (mean value 21.85 ± 24.25 mug/m3), although the two series of data (n=20) were significantly correlated.
Even if the Co and Ni urinary concentration values (n=45) recorded on Monday morning and Thursday evening were significantly correlated, at the end of the week there was a 3-fold increase, specifically, from 7.3 to 22.28 mug/l, in Co elimination (a significant difference) and a 30% increase in Ni elimination from 11.98 to 15.83 mug/l. Moreover, on Monday morning, 90% of Ni urinary concentration values were higher than those of Co as opposed to only 33%, on Thursday evening.
In the six cases in which both airborne and urine determinations were performed on the 2 days, no significant relationship was found between external exposure and biological monitoring data. (...)
Mots-clés Pascal : Cobalt, Nickel, Métal lourd, Exposition professionnelle, Industrie métallurgique, Homme, Association toxique, Interaction toxique, Pharmacocinétique, Toxicocinétique, Surveillance biologique, Médecine travail
Mots-clés Pascal anglais : Cobalt, Nickel, Heavy metal, Occupational exposure, Metallurgical industry, Human, Toxic association, Poison interaction, Pharmacokinetics, Toxicokinetics, Biological monitoring, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0121757
Code Inist : 002B03L05. Création : 22/06/1998.